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Where does the CSF protein come from in bacterial meningitis?

Discussion in 'Step I' started by IheartCaffeine, Mar 1, 2007.

  1. IheartCaffeine

    IheartCaffeine I really do. 5+ Year Member

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    Nov 27, 2005
    California
    Where does the CSF protein come from in bacterial meningitis?
    What determines opening pressure?

    Thanks!!
     
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  3. Teejay

    Teejay Team Player 2+ Year Member

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    Nov 18, 2006
    It is caused by increased vessel permeability. The protein source is probably from serum protiens that leak into the CSFmembrane.
     
  4. Time

    Time Member 5+ Year Member

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    Jul 4, 2004
    Citation, if you dont mind?
     
  5. Roy7

    Roy7 Senior Member 10+ Year Member

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    Feb 1, 2004
    Washington DC
    Just reading it, that's everywhere man (hard to name a spot where you read it) - but, while this isnt a formal journal, its on page 576 of Rapid Review (under bullet 4).
     
  6. basupran

    basupran ortho, study, cars, lift 10+ Year Member

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    Jan 24, 2003
    NY
    Elevated albumin ratio, normal index, and no bands

    The elevated CSF albumin/serum albumin indicates increased permeability of the blood brain barrier. This occurs most commonly in inflammatory or immune processes involving the CNS. The normal IgG index suggests no increased IgG synthesis in the CNS. However, increased permeability of the blood brain barrier can mask moderate increases in CNS IgG synthesis. No oligoclonal bands are seen in the gamma region.
    .

    From
    http://dpalm.uth.tmc.edu/clinicalservices/Interps/CSFint.html
     
  7. nvshelat

    nvshelat Senior Member 7+ Year Member

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    Mar 8, 2005
    So why decreased glucose if incr permeability?
     
  8. PeepshowJohnny

    PeepshowJohnny 2+ Year Member

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    Jun 28, 2007
    Earth
    Not sure if this is the "correct" pathophys, but I had it explained to me that glucose decreases due to metabolism by bacteria and the WBC's in CSF and stays down due to dysfunction in glucose transporters into the CSF caused by the inflammation.
     
  9. nvshelat

    nvshelat Senior Member 7+ Year Member

    970
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    Mar 8, 2005
    Yes! This is correct... figured that out a couple hrs after I posted as thats also what a bunch of my friends said.
     
  10. MSKalltheway

    MSKalltheway I got the magic stick 7+ Year Member

    832
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    Jan 16, 2007
    +1, well said.
     

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