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Where does the CSF protein come from in bacterial meningitis?

Discussion in 'Step I' started by IheartCaffeine, Mar 1, 2007.

  1. IheartCaffeine

    IheartCaffeine I really do.
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    Where does the CSF protein come from in bacterial meningitis?
    What determines opening pressure?

    Thanks!!
     
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  3. Teejay

    Teejay Team Player
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    It is caused by increased vessel permeability. The protein source is probably from serum protiens that leak into the CSFmembrane.
     
  4. Time

    Time Member
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    Citation, if you dont mind?
     
  5. Roy7

    Roy7 Senior Member
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    Just reading it, that's everywhere man (hard to name a spot where you read it) - but, while this isnt a formal journal, its on page 576 of Rapid Review (under bullet 4).
     
  6. basupran

    basupran ortho, study, cars, lift
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    Elevated albumin ratio, normal index, and no bands

    The elevated CSF albumin/serum albumin indicates increased permeability of the blood brain barrier. This occurs most commonly in inflammatory or immune processes involving the CNS. The normal IgG index suggests no increased IgG synthesis in the CNS. However, increased permeability of the blood brain barrier can mask moderate increases in CNS IgG synthesis. No oligoclonal bands are seen in the gamma region.
    .

    From
    http://dpalm.uth.tmc.edu/clinicalservices/Interps/CSFint.html
     
  7. nvshelat

    nvshelat Senior Member
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    So why decreased glucose if incr permeability?
     
  8. PeepshowJohnny

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    Not sure if this is the "correct" pathophys, but I had it explained to me that glucose decreases due to metabolism by bacteria and the WBC's in CSF and stays down due to dysfunction in glucose transporters into the CSF caused by the inflammation.
     
  9. nvshelat

    nvshelat Senior Member
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    Yes! This is correct... figured that out a couple hrs after I posted as thats also what a bunch of my friends said.
     
  10. MSKalltheway

    MSKalltheway I got the magic stick
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    +1, well said.
     

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