IheartCaffeine

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Where does the CSF protein come from in bacterial meningitis?
What determines opening pressure?

Thanks!!
 

Roy7

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Just reading it, that's everywhere man (hard to name a spot where you read it) - but, while this isnt a formal journal, its on page 576 of Rapid Review (under bullet 4).
 
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basupran

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Elevated albumin ratio, normal index, and no bands

The elevated CSF albumin/serum albumin indicates increased permeability of the blood brain barrier. This occurs most commonly in inflammatory or immune processes involving the CNS. The normal IgG index suggests no increased IgG synthesis in the CNS. However, increased permeability of the blood brain barrier can mask moderate increases in CNS IgG synthesis. No oligoclonal bands are seen in the gamma region.
.

From
http://dpalm.uth.tmc.edu/clinicalservices/Interps/CSFint.html
 

PeepshowJohnny

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Not sure if this is the "correct" pathophys, but I had it explained to me that glucose decreases due to metabolism by bacteria and the WBC's in CSF and stays down due to dysfunction in glucose transporters into the CSF caused by the inflammation.
 

nvshelat

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Not sure if this is the "correct" pathophys, but I had it explained to me that glucose decreases due to metabolism by bacteria and the WBC's in CSF and stays down due to dysfunction in glucose transporters into the CSF caused by the inflammation.

Yes! This is correct... figured that out a couple hrs after I posted as thats also what a bunch of my friends said.
 

MSKalltheway

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Not sure if this is the "correct" pathophys, but I had it explained to me that glucose decreases due to metabolism by bacteria and the WBC's in CSF and stays down due to dysfunction in glucose transporters into the CSF caused by the inflammation.

+1, well said.
 
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