Heh... Addictive caries vaccines? Maybe that would be a good thing.
😛 Seriously though, that tobacco-derived vaccine is actually a purified IgA produced by genetically-modified tobacco plants (Cario Rx, being developed by a company called Planet Biotechnology) and probably have little if any nicotine. We can probably expect it to be held up for testing by the FDA for years though before it ever sees the light of day.
Anyway... I have some more discussion here for Frank:
The thing with our saliva is that it forms the pellicle on our teeth which provides a surface of attachment for all the bacteria. Unless we can figure a way to prevent the pellicle from forming, there isn't any way to "teflon-ize" our teeth so that nothing can stick to them. The vaccine might prevent Strep Mutans from sticking to teeth, but I don't think it would have much effect on the other bugs that causes periodontal disease like Porphorymonas Gingivalis, Bacteroides Forsythus or Strep Sanguis etc. That's why I think periodic checkups and regular cleanings are still important.
A systemic vaccine unfortunately will not do much to destroy periodontitis-causing bacteria because there is no bloodflow in our sulcular pockets (normally anyway, heh) and definitely none above the gumline unless you have a mucosal laceration or something!.
😀
We can prevent inflammatory breakdown of our periodontium right now using Doxycycline, which is a tetracycline derivative. It does NOT act through killing bacteria though because there is no way for our bloodstream to deliver it into our periodontal pockets. It works by inhibiting the metalloproteinases active during inflammation that would otherwise destroy collagen and thus periodontal attachment. However, this does NOT remove the etiology (i.e. the cause of the inflammation)!
As far as regular checkups for kids go: I'm not just talking about severe malocclusion. You can have your teeth all nice and straight with good archforms but still have a Skeletal Class II or Class III relationship. These definitely need to be intercepted as early as possible unless you want to grow up looking like Beavis (Skeletal Class III, mandibular prognathic) or Butthead (Skeletal Class II maxillary prognathic or mandibular retrognathic).
This is Definitely NOT comparable to a 20-year-old guy being screened for PSA-- Dental checkups for kids are definitely appropriate no matter which way you cut it.
"Yeah! Angle Class I occlusion RULES!!" Huh huh, huh huh huh.
Gimme some credit here. I might have fallen asleep in class a few times (who hasn't?) but for the most part I've paid attention in lecture in the past three years.
😉