Why do steroids cause an increase in WBC?

Discussion in 'Medical Students - MD' started by Digginit, Sep 16, 2003.

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  1. Digginit

    Digginit Junior Member 7+ Year Member

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    Oct 28, 2002
    What's the mechanism for it? Surely some really smart medical student knows.....

    Digginit!
     
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  3. ckent

    ckent Banned Banned

    2,138
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    Jul 31, 2000
    Smallville/Metropolis
    It causes white blood cells to be released from endothelial walls and go into the blood stream, allowing them to be counted in your CBC.
     
  4. dr barb

    dr barb Member 7+ Year Member

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    Dec 17, 2002
    LA (NOT Louisiana)
    Steroids increase the concentration of neutrophils in your blood (causing and increase in WBC's but without bandemia) by preventing their infiltration to the site of injury, and hence, directing them to the circulation instead of the injured tissue. These are mature neutrophils so you don't see an increase in bands (immature neutrophils).
     
  5. Talula

    Talula Junior Member 7+ Year Member

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    May 27, 2003
    Yep, a phenomenon also known as "demargination." Gotta give it a name that the 'lay' public doesn't understand to make us feel super smart :rolleyes:
     
  6. phllystyl

    phllystyl n0t the j0ke [email protected]@ 7+ Year Member

    ]


    I actually think demargination is a perfect descriptor of it, just as margination is perfect descriptor of the opposite.
     
  7. Digginit

    Digginit Junior Member 7+ Year Member

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    Oct 28, 2002
    Great! Thanks!
     

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