The superficial layers - layers II and III - of EC project to the
dentate gyrus and
hippocampus: Layer II projects primarily to
dentate gyrus and hippocampal region CA3; layer III projects primarily to hippocampal region CA1 and the
subiculum. These layers receive input from other cortical areas, especially associational,
perirhinal, and
parahippocampal cortices, as well as
prefrontal cortex. EC as a whole, therefore, receives highly-processed input from every sensory modality, as well as input relating to ongoing cognitive processes, though it should be stressed that, within EC, this information remains at least partially segregated.
The deep layers, especially layer V, receive one of the three main outputs of the
hippocampus and, in turn, reciprocate connections from other cortical areas that project to superficial EC.
The rodent entorhinal cortex shows a modular organization, with different properties and connections in different areas.