Why would you try to put the burden back on a PI who has made clear that she is swamped and given you an opportunity? Start strong: “Wonder Child has been an outstanding addition to [X lab]—one of the best I have seen in my 20 years.” Explain how she knows you and make clear that she knows you well. Then pick three or four examples that demonstrate excellence in the lab and translate to medical school—e.g., You designed an innovative research project and, despite a few early setbacks, dutifully saw it through to the end—with impressive results. Early on, you showed a strong drive and worked tirelessly to acquire the necessary bench skills. Explain with examples. As you progressed in the lab, you brought other students your wing, taught them the skills you had previously mastered, and were eager to help them succeed. Explain with examples. In weekly meetings, you demonstrated a mastery of the material, were able to break down complex concepts into palatable bites, and clearly convey them to others in the group. Explain with examples. You drafted and revised the results of your research into a fine article that was accepted for publication, working independently but also listening carefully and taking direction where warranted. Explain with examples. Finally, conclude with a short paragraph that reiterates that you were an outstanding member of the lab who has the skills, drive and traits necessary to be a lifelong learner, an excellent medical student and doctor. In addition to providing the PI with a draft letter, provide her with a copy of any materials you think are relevant should she wish to modify it (e.g., your CV, PS, etc.)