Step I Drug of Choice for Chlamydia ?
Started by HelpPleaseMD
I got a quick follow up question. FA states that macrolides are also effective against Neisseria so why add ceftriaxone?
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Yea your absolutely right. I saw the azithromycin / ceftriaxone combo more than a couple of times in UWORLD. Was just curious after reviewing FA
High azithro resistance in gonorrhea
Used to be able to do that. Also used to be able to use a fluoroquinolone for monotherapy for GC + Chlamydia (not even that long ago--I was taught that when I went through ID in 2006). No more due to the crazy resistance gonococcus is developing.
Uh... in the real world, if you find urethral discharge, you give Ceftriaxone and Doxy. Just sayin...
though when you're old enough to perscribe for yourself, Cipro Doxy or Cipro Azithro work too, but they are backups
Yes.
Chlamydia - single-dose azithro or doxy (since it's intracellular, you need to use a protein synthesis inhibitor, like a macrolide or a tetracycline)
Gonorrhea - single-dose cefiximine or ceftriazone (extracellular, so cefalosporins are legit)
I think you need to assume coinfection with urethritis, which is why you should use both. Also, gonorrhea tends to change its pilus a lot, so reinfection may occur (got a UWorld question on this). But, this is not true of neisseria meningitidis (I'm bad at spelling - sorry!), for which there is a vaccine.
Chlamydia - single-dose azithro or doxy (since it's intracellular, you need to use a protein synthesis inhibitor, like a macrolide or a tetracycline)
Gonorrhea - single-dose cefiximine or ceftriazone (extracellular, so cefalosporins are legit)
I think you need to assume coinfection with urethritis, which is why you should use both. Also, gonorrhea tends to change its pilus a lot, so reinfection may occur (got a UWorld question on this). But, this is not true of neisseria meningitidis (I'm bad at spelling - sorry!), for which there is a vaccine.
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Very high yield, well-summarized post. There were so many UWorld questions on treating Chlamydia and Gonorrhea empirically as co-infection...maybe 3 or 4... e.g. "if person is treated with ceftriaxone and not getting better, why?"
