Had the same issue when starting out. I think what helped me were a few things. First, wirte down pages the disease is also mentioned in FA. Tuberous Sclerosis comes to mind, as it is mentioned in like 3 spots in FA. Each time you run into a disease, drug, or any other topic, note pages you have seen it before. It will do WONDERS later when going through it again. Second, write down similaties, example: Whipples and a1AT, both have + PAS. I think that this kinda helps you integrate multiple diseases and their tests/findings/etc. Third (and the most difficult for me) was to keep it simple and short. After 2 months my FA looked like a child had gotten ahold of magic markers and then decided to have a tonic-clonic seizure while coloring in my book. By the end, I had annotated TOO much. I couldn't seperate the important from the minutia, and it made me pretty much force myself to skip a lot of my annontations. Lastly, try to circle one or two big topics per disease/drug/condition and know it cold. THEN build. I found trying to memorize all the little things about a disease lead me down a path of amnesia. I couldn't remember anything a day later. Start BIG, for instance, know a FEW of the SE of Phenytoin (teratogenic, SJS,...) then build on subsequent times you go through FA. You MUST KNOW the big topics, then work in the smaller ones, or it will become mush (which happened to me in the beginning of me studying). If you have any other questions feel free to fire me a PM. Good luck.