1,000Xs stronger than morphine & 10Xs stronger than fentanyl, meet Dsuvia

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IV sufentanil has been available for anesthesia for years now. this is a different formulation.

might be helpful in pre-an or acute postop pain.

and before we go off the deep end - these are limited to hospital settings, and at 30 mcg, assuming it is 1000 times stronger than morphine, each single dose pill in each individual wrapper is as "strong" as a 30 mg morphine pill.
 
Ducttape said:
IV sufentanil has been available for anesthesia for years now. this is a different formulation.

might be helpful in pre-an or acute postop pain.

and before we go off the deep end - these are limited to hospital settings, and at 30 mcg, assuming it is 1000 times stronger than morphine, each single dose pill in each individual wrapper is as "strong" as a 30 mg morphine pill.
Click to expand...
What could possibly go wrong?
 
emd123 said:
What could possibly go wrong?
Click to expand...

Has Opioid Hysteria Risen to the Point Where Innovation Is Forbidden?

Commissioner Gottlieb also stated in the FDA announcement:

"We owe an answer to patients with medical pain, and the innovators who take risks to develop products to help address their needs. We owe it to Americans who want the FDA to do our part to help end one of the biggest addiction crises of modern times, while we carefully balance these grave risks against patient needs."
 
drusso said:
Has Opioid Hysteria Risen to the Point Where Innovation Is Forbidden?

Commissioner Gottlieb also stated in the FDA announcement:

"We owe an answer to patients with medical pain, and the innovators who take risks to develop products to help address their needs. We owe it to Americans who want the FDA to do our part to help end one of the biggest addiction crises of modern times, while we carefully balance these grave risks against patient needs."
Click to expand...

Again though, what was the actual need for this? The problem doesn't seem to be that people's pain isn't adequately controlled because the current opioids we have aren't strong enough. The problem is that people get dependent on them, addicted to them, then overdose and die (or ruin their lives). What need d0es this drug address besides the need for money in the pocket of AcelRx? What's the current problem with using fentanyl lollipops for acute injuries in the military?
 
We already have several fentanyl products on the market that are an improvement in rapidity of onset compared to sublingual sufentanil. It is perplexing why the FDA would introduce another more potent opioid that will be abused, causing respiratory depression and addiction.
 
Ducttape said:
IV sufentanil has been available for anesthesia for years now. this is a different formulation.

might be helpful in pre-an or acute postop pain.

and before we go off the deep end - these are limited to hospital settings, and at 30 mcg, assuming it is 1000 times stronger than morphine, each single dose pill in each individual wrapper is as "strong" as a 30 mg morphine pill.
Click to expand...

True, but this is sublingual, not oral. Still, I'm not too worried this. Sometimes people get 2mg IV Dilaudid repeatedly postop. This isn't that different except it will clear faster. Biggest problem will be nurses pocketing it and selling on the street for a bazillion dollars imo, but no different really than pocketing IV formulations.
 
sufentanil has a shorter half life than fentanyl. equal or slightly faster onset of analgesia. that might be the reason the military wants it.
 
Didnt AcelRx say it wasn’t addictive? LOL. Oh wait that was oxycodone or was it morphine, no maybe it was diacetyl morphine.
 
should purge the addict anesthesiologists pretty quick
 
I mean, come on. Why are we approving stuff like this.
 
Apparently we didn’t learn our lessons from subsys
 
According to the pharmacokinetic data, Fentora has a faster onset than Dsuvia. Therefore, there is absolutely no need at all for this drug. Rather than unleash another drug on society that will be abused, the FDA could have simply expanded the use of Fentora.
 
This is a case of a medication being approved that isn't needed. This will result in the company through their reps, aggressively pushing it for just about every damn thing because they need to create a market for it. There was a market for IV sufenta to some extent (ie. Cardiac anesthesia, etc), but oral sufenta? Why the hell is this needed? In a world with MULTIPLE formulations of morphine, dilaudid, oxycodone, oxymorphone, hydrocodone, and FENTANYL...is there REALLY a need for a new damn molecule‽ And not even really a new one, just a new way for it to enter the bloodstream! Next they'll approve a transmucosal Remifentanyl and undoubtedly start marketing it as "overdose proof" since it has such a rapid offset profile. Just wait and see...
 
algosdoc said:
According to the pharmacokinetic data, Fentora has a faster onset than Dsuvia. Therefore, there is absolutely no need at all for this drug. Rather than unleash another drug on society that will be abused, the FDA could have simply expanded the use of Fentora.
Click to expand...

Devil's advocate: I kind of like having choices, and I doubt these rapid on/off narcotics are going to be widely abused unless drug houses start continuous infusions. Again, I'm not in a field where I will order ANY of these meds.
 
I’m sure it’ll be super controlled and have absolutely no abuse/diversion/illicit potential. 😉
 
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