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Assuming these are questions from secondaries: your personal statement was a generic statement of "why medicine/medical school" vs an autobiographical statement on a secondary I'd approach it as "what makes you you" (and by extension why you are a good candidate for the school).
 
helloitsodin said:
How do these two differ? (Like for example, University of Washington’s Autobiographical statement). How differently should we approach it?
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From their website:

"The following are required in the Secondary Application:
  1. An autobiographical statement which should include (250 word limit):
    • the origin and development of your motivation to be a physician
    • your prior experiences in health care
    • steps taken to explore a career in medicine
    • your eventual goals as a physician
    • personal attributes that would make you a good physician
    • Please do not repeat what you wrote in your AMCAS Personal Comments (this will already be on file with our office). If you have already covered all of the above topics in your AMCAS application, use this space to let the Admissions Committee know who you are in addition to being someone who wants to be a physician." The Applications | UW Medicine
 
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