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I have a friend with a 490-499 and 3.9x gpa with no II from TMDSAS schools and some AMCAS schools. Also, they are TX in-state, URM, and served in the military. They also have loads of research with cancer, obesity, and DM.
 
If you go in some of the DO school specific threads there are some sub-500 MCATs getting interviews. Some schools have averages of 500-502 so you know there will be some with sub 500 scores. These people probably have high GPAs and good extracurriculars though. If you’re talking about strictly MD probably not.
 
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