A few questions about research

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Schnitzy

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Hello,

Let me start by saying that I read the FAQs, and I've read several old threads on research, however, I still have a few questions.

I'm a M2 at a middle-of-the-road MD program (my school has a radonc department, but no residency), I'm in the top 1/4 of my class, and I've done quite a bit of radonc shadowing. I am planning on applying for fellowship years (HHMI, DD, NIH) next fall, and I want to make sure I'm approaching all of this correctly.

I did research in college and after college for a few years, and in total, I earned 5 pubs (4 basic, 1 clinical; 2 first authorships), and so far in med school, I have 1 first authored publication in public health (thus, 6 total, 3 of which are first authorships). However, none of these papers are in radiation oncology/cancer. I have also been working on a clinical research project for the past year, however, the research is with hematologic malignancies, not solids. So, my first question is whether my publications--particularly my malignant hematology project--will be looked upon favorably given that they are not in radiation oncology/solid cancer research?

Having read through the ASTRO abstracts, the vast majority of papers are clinical, but there are occasional basic papers, too. Since I do not have any radiation oncology research, for fellowship year programs, is it better to do clinical research in radiation oncology than basic cancer research with a PI who may or may not be a radiation oncologist? Below, I pasted one of the posts (by the Dos Equis guy) from the FAQ, but in several of the threads, Neuronix has highly recommended clinical rad onc research over basic cancer research (I'm assuming this is partially due to the obvious fact that with only a year, it's easier to be productive in clinical than in basic research). Therefore, I'm curious what all of you think: it is better to do clinical research in a fellowship year, or is basic research equally as helpful? The reason why I am asking so early is that I would rather do the HHMI-scholars program over DD or NIH-CRTP, which means over the next few months, I need to start stalking and asking around about potential PIs

Thanks!

"Ideally, the research should be in Radiation Oncology but the exception is if you are doing a PhD or HHMI/DD. In those cases, basic research applicable to cancer is fine. If you do research in an area completely unrelated to cancer it may not help you very much . . . mainly because most Rad Onc attendings on admissions committess are not sophisticated enough to figure out what you actually did."
 
I think your research background is already enough and I would just focus on projects that you are interested in doing or that's available to work on. You have already proven you can do research, I would just focus on abstracts in the field to present at ASTRO and establishing connections.

Clinical research in my opinion is faster to publish but if you like basic science, I definitely don't think it would be a problem for you specifically based on your previous work.

-R
 
Below, I pasted one of the posts (by the Dos Equis guy) from the FAQ

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You need Rad Onc specific research. However, if you have a lot of other research published (non-Rad Onc) a couple of abstracts specifically in Rad Onc would be fine. Most applicants do clinical research because it is straightforward and manageable in scope and (important) can be published relatively quickly. I would not recommend Rad Onc specific bench research unless you are going for an MD-PhD or (like you) are planning to take a year off for research.
 
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You need Rad Onc specific research. However, if you have a lot of other research published (non-Rad Onc) a couple of abstracts specifically in Rad Onc would be fine. Most applicants do clinical research because it is straightforward and manageable in scope and (important) can be published relatively quickly. I would not recommend Rad Onc specific bench research unless you are going for an MD-PhD or (like you) are planning to take a year off for research.

Thank you very much. I just want to make sure I am understanding the bolded point: you're saying that if I do basic research, it should be with a rad onc PI.

I've looked at rad onc programs at different universities, and the majority of attendings are not doing basic research, but the ones who are are doing generic molecular bio/genetics cancer research, not radiation biology research. Would it be OK to do non-radiation cancer research, or should I aim specifically for radiation biology research?

Thank you again for your help
 
I disagree the research has to be in rad onc. If you have a good opportunity in med onc or surg onc that would carry similar weight.
 
Thank you very much. I just want to make sure I am understanding the bolded point: you're saying that if I do basic research, it should be with a rad onc PI.

I've looked at rad onc programs at different universities, and the majority of attendings are not doing basic research, but the ones who are are doing generic molecular bio/genetics cancer research, not radiation biology research. Would it be OK to do non-radiation cancer research, or should I aim specifically for radiation biology research?

Thank you again for your help
You can also look into labs that are doing DNA DSB repair and/or DNA damage response types of bench research if you're interested. It's not strict radiobiology, but still highly relevant to radiotherapy.
 
Would it be OK to do non-radiation cancer research, or should I aim specifically for radiation biology research?

Part of the reason to do research is to work with a radiation oncologist for LOR purposes. If it's a radiation oncologist doing bench cell biology, I think that works. I still think it's best to at least keep your hand in clinical work. It's very easy to spend a year working in "basic science" and not get a first author publication. MD/PhDs work for four years in their PhDs establishing new projects and often only publish one or two papers.

In clinical research it's much easier to publish. You can argue back and forth about whether it's more important to have basic or clinical research (I think to most programs it doesn't matter much...), but it's definitely important to have publications to show for your research efforts.
 
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