AAMC #4 item 100

[EnginrTheFuture]

Out of the options available, there is a clear winner BUT since acetylcholinesterase is a common topic I have a question.

If acetylcholinesterase is applied, wouldn't it increase both ParaSympathetic and Sympathetic stimulation equally? Yes, sympathetic has epinephrine/nor at the effector junction but wouldn't the increased acetylcholine at the ganglionic junction increase the epinephrine at the effector?

I guess since the epinephrine can get broken down and the acetylcholine can't, the sympathetic motor junction would "run out" of epinephrine or burn out in a sense over time?

Just wondering why the continued stimulus of both S and PS ganglions wouldn't continually stimulate the motor junction despite what neurotransmitter it uses.

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[MedPR]

Out of the options available, there is a clear winner BUT since acetylcholinesterase is a common topic I have a question.

If acetylcholinesterase is applied, wouldn't it increase both ParaSympathetic and Sympathetic stimulation equally? Yes, sympathetic has epinephrine/nor at the effector junction but wouldn't the increased acetylcholine at the ganglionic junction increase the epinephrine at the effector?

I guess since the epinephrine can get broken down and the acetylcholine can't, the sympathetic motor junction would "run out" of epinephrine or burn out in a sense over time?

Just wondering why the continued stimulus of both S and PS ganglions wouldn't continually stimulate the motor junction despite what neurotransmitter it uses.

I don't know the context of the question, but if you increase AchE you would decrease the concentration of Ach in the NMJ and would decrease stimulation of the muscle.

 

[EnginrTheFuture]

Bump for anyone who has the book handy?

 

[pfaction]

This question is straight pharmacology for me.

Atropine is an antimuscarinic agent used to dilate the eyes. If it's antimuscarinic, it has the opposite effects of AChE. AChE administration would thus constrict the pupils, resembling the alpha agonism of using something like epinephrine in the eyes--I think no one uses propine anymore but whatever.

#95 gives away the answer to #100.