activator vs repressor binding

[m25]

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In transcription regulation, do activators normally bind to the promoter while repressors bind to the operator?

 

[Czarcasm]

In transcription regulation, do activators normally bind to the promoter while repressors bind to the operator?

Based on most examples I'm familiar with, that seems true. In Prokaryotes, repressors in their active state bind to the operator. Activators can bind within the promoter, but I believe there are also some instances just upstream of the promoter as well (not 100% certain on this though).

 

[amy_k]

Yes, activators usually bind either directly to the promoter or to an enhancer in the near vicinity, whereas repressors normally bind directly to, or on a silencer near to, the operator. Obviously there are exceptions to this generalization.