adiponectin

[Little Soldier]

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guys i cant seem to find any answer to this question anywhere, why does adiponectin decrease in obesity? i understand its negatively expressed compared to body fat percentage but why is that the case - if its functions serve as an anti obesity sort of thing then why isnt it positively correlated with body fat?

 

[cage92]

guys i cant seem to find any answer to this question anywhere, why does adiponectin decrease in obesity? i understand its negatively expressed compared to body fat percentage but why is that the case - if its functions serve as an anti obesity sort of thing then why isnt it positively correlated with body fat?

hey bcz it is antiinflammatory product and they saiid that obeisity is state of inflammation due to realease all cytokines from adipose tissue execpt adiponection which wiill decline during obeisity

where did you face this question? uworld?

 

[Myxedema]

guys i cant seem to find any answer to this question anywhere, why does adiponectin decrease in obesity? i understand its negatively expressed compared to body fat percentage but why is that the case - if its functions serve as an anti obesity sort of thing then why isnt it positively correlated with body fat?

It it not body fat percentage per se, but the size of adipocytes themselves. As the adipocytes get larger, they secrete less adiponectin. Adiponectin normally increases beta-oxidation of fatty acids and decrease blood glucose (via inhibition of gluconeogenesis in liver and increased GLUT4 translocation in muscle). Decreased adiponectin levels will result in less fatty acid oxidation and more insulin resistance, i.e. metabolic syndrome. So, perhaps, it can also be said that not only obesity is associated with decreased adiponectin levels, but decreased adiponectin levels will result in further increases in obesity.

 

[Little Soldier]

thats my point. why would it decrease the larger the adipocytes are. thats like saying the liver having so much glucose that it begins to inhibit glycolysis.

 

[Myxedema]

thats my point. why would it decrease the larger the adipocytes are. thats like saying the liver having so much glucose that it begins to inhibit glycolysis.

Obviously, it would have been better for the body if adiponectin increased with increased adipocyte size. That way, the body would have had an important defense mechanism against metabolic syndrome. Unfortunately, rather than trying to maintain homeostasis, excess fat deposition lead to metabolic derangements within adipocytes, leading to decreased adiponectin secretion.

I think the fine point here is the difference between the fat-storing function and endocrine function of adipocytes.