AIS Testosterone levels (FA vs. RR Goljan)

[sivman17]

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FA says in Androgen Insensitivity Syndrome there are increased levels of Testosterone, Estrogen, and LH. This makes sense to me since there are defective androgen receptors and they won't be feeding back on the AP. But, Goljan's RR Pathology says there are normal levels of T and DHT, and slightly increased levels of LH and estradiol levels.

So, both of them say there is increased LH and Estrogen, but Goljan states that the increased LH isn't increasing Testosterone.

Does anyone know which one is right?


For reference: Goljan p. 95; FA 2011 p. 486

 

[nitpick]

FA says in Androgen Insensitivity Syndrome there are increased levels of Testosterone, Estrogen, and LH. This makes sense to me since there are defective androgen receptors and they won't be feeding back on the AP. But, Goljan's RR Pathology says there are normal levels of T and DHT, and slightly increased levels of LH and estradiol levels.

So, both of them say there is increased LH and Estrogen, but Goljan states that the increased LH isn't increasing Testosterone.

Does anyone know which one is right?


For reference: Goljan p. 95; FA 2011 p. 486

Checked from Harrison 17th Edition- Gonadotrophins and Testosterone can be normal,elevated or even decreased depending upon the severity of mutation and due to feedback inhibition of estrogen on the hypothalmo-pitutary axis.
So FA and Goljan both are wrong. But for exam consider all are increased as it's most common scenario.

 

[sivman17]

Checked from Harrison 17th Edition- Gonadotrophins and Testosterone can be normal,elevated or even decreased depending upon the severity of mutation and due to feedback inhibition of estrogen on the hypothalmo-pitutary axis.
So FA and Goljan both are wrong. But for exam consider all are increased as it's most common scenario.

That makes sense. Thanks, np