Anemia and osteolytic bone

[Peerapat CMU Med]

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I wonder how anemia diseases, for example thalassemia, cause osteolytic lesion. I'm a first year clinical medical student and studying in radiology section. I got an x-ray film of thalassemia patient which show the extramedullary hematopoiesis ( dense lesion ), but I don't understand why thalassemia cause the osteolytic lesion too which shown the course trabecular appearace.
( Excuse my poor grammar T T )

 

[Styrene]

I wonder how anemia diseases, for example thalassemia, cause osteolytic lesion. I'm a first year clinical medical student and studying in radiology section. I got an x-ray film of thalassemia patient which show the extramedullary hematopoiesis ( dense lesion ), but I don't understand why thalassemia cause the osteolytic lesion too which shown the course trabecular appearace.
( Excuse my poor grammar T T )

Hypertrophic and hyperplastic marrow response leads to expansion of the medulla, thinning of the cortex, destruction of trabeculae, and overall osteopenia with focal areas of lucency due to erosion of the cortex. The marrow ends up proliferating in the subperiosteal space.

Source: Medscape reference article about imaging in thalassemia.

I believe these findings are still not fully understood.

 

[Peerapat CMU Med]

Hypertrophic and hyperplastic marrow response leads to expansion of the medulla, thinning of the cortex, destruction of trabeculae, and overall osteopenia with focal areas of lucency due to erosion of the cortex. The marrow ends up proliferating in the subperiosteal space.

Source: Medscape reference article about imaging in thalassemia.

I believe these findings are still not fully understood.

Thank you 🙂