Antacid qu.

[Ramoray]

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I was just looking in FA about antacids and it lists 3. Alum hydrox, mag hydrox and Calcium Carbonate. In FA it says that all 3 cause Hypokalemia. I am wondering why Alum OH, and Mag OH would because they are neutralization rxns and not net base is produced therefore no metabolic alkalosis and that would mean no hypokalemia in my eyes. Even in Katzung it does mention that no excess base is produced by those 2 due to complete neutralization- so wouldnt that mean no hypokalmia in those 2? I mean i see why Calc Carb or NaHco3 would produce base upon reacting with HCL and produce alkalosis and therefore hypokalemia.. ok any help woul be appreciateed

 

[omarsaleh66]

Anytime u neutralize acid or decrease H+, then the cells will release H+ to avoid metabolic alkalosis in exchange for K+. So when H+ is released into teh serum from the cells, the K+ from the serum is taken up into the cells giving u hypokalemia.

later