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I've known 5 people so far that can either not tolerate SSRIs (I'm talking being put on almost everyone and SNRIs) at all or at extremely low dosages without getting something such as feeling naseous, weak, and dizzy. After the 4th, I noticed they all had a commonality.
These patients all had some type of immunological problem. Three
had Epstein Barr virus that led to infectious mononucleosis, and they later developed chronic fatigue syndrome, another has Sjogren's syndrome, another had Guillian Barre syndrome as a child.
I did further investigation into this and noticed several forums where people with chronic fatigue syndrome also mentioning they could not tolerate medications except at the lowest dosages, where unfortunately these medications had barely any effect.
In one of those cases, the guy had an anxiety disorder so bad, and was on benzos for years (and he wanted off of them because he felt drunk 24/7 and he did not like it), a highly acclaimed institution in the area hosptalized him (at my request...because I knew the docs there would actually give a damn and not just discharge him 48 hours later) and had to monitor his vital signs frequently while he was put on a minimal dosage of Citalopram. His BP went to very high levels (diastolic over 110), and he developed herpetic like lesions around his mouth, finally after about 5 days he stopped having these side effects with the medications.
I developed a theory that perhaps their inability to tolerate the medication is immunologically based, but despite several patients talking about this phenomenon over the internet in various chronic fatigue syndrome support forums, I've never seen any documentation on this in any medical journals and have not found much in literature searches.
Anyone experience something similar? I was thinking if a tally of patients could be pooled, this could lead to an article being published.
These patients all had some type of immunological problem. Three
had Epstein Barr virus that led to infectious mononucleosis, and they later developed chronic fatigue syndrome, another has Sjogren's syndrome, another had Guillian Barre syndrome as a child.
I did further investigation into this and noticed several forums where people with chronic fatigue syndrome also mentioning they could not tolerate medications except at the lowest dosages, where unfortunately these medications had barely any effect.
In one of those cases, the guy had an anxiety disorder so bad, and was on benzos for years (and he wanted off of them because he felt drunk 24/7 and he did not like it), a highly acclaimed institution in the area hosptalized him (at my request...because I knew the docs there would actually give a damn and not just discharge him 48 hours later) and had to monitor his vital signs frequently while he was put on a minimal dosage of Citalopram. His BP went to very high levels (diastolic over 110), and he developed herpetic like lesions around his mouth, finally after about 5 days he stopped having these side effects with the medications.
I developed a theory that perhaps their inability to tolerate the medication is immunologically based, but despite several patients talking about this phenomenon over the internet in various chronic fatigue syndrome support forums, I've never seen any documentation on this in any medical journals and have not found much in literature searches.
Anyone experience something similar? I was thinking if a tally of patients could be pooled, this could lead to an article being published.
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