aspirin and prothrombin time?

[WashMe]

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so I'm looking at kaplan's master the boards for step 3 (2nd ed) and it says on p. 494 that the PT is elevated in aspirin overdose because "aspirin interferes with the production of vitamin K-dependent clotting factors". Did I miss the memo? I've looked around but I cannot find a verification of this assertion elsewhere.

All I can find is that aspirin inhibits platelet aggregation, modulates signaling through NF-KB, and may induce NO production. I don't see where/how it affects the clotting factors to affect PT/INR.

Any thoughts?

Thanks!

 

[yesno]

If you check wiki it says that aspirin only affects bleeding time. Clotting factors would be affected in liver failure. So i guess if you associate Reye with aspirin.

 

[Rx MPLS]

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[SpecterGT260]

so I'm looking at kaplan's master the boards for step 3 (2nd ed) and it says on p. 494 that the PT is elevated in aspirin overdose because "aspirin interferes with the production of vitamin K-dependent clotting factors". Did I miss the memo? I've looked around but I cannot find a verification of this assertion elsewhere.

All I can find is that aspirin inhibits platelet aggregation, modulates signaling through NF-KB, and may induce NO production. I don't see where/how it affects the clotting factors to affect PT/INR.

Any thoughts?

Thanks!

Sounds like coumadin

Sent from my DROID RAZR using SDN Mobile

 

[topsurgeon2010]

so I'm looking at kaplan's master the boards for step 3 (2nd ed) and it says on p. 494 that the PT is elevated in aspirin overdose because "aspirin interferes with the production of vitamin K-dependent clotting factors". Did I miss the memo? I've looked around but I cannot find a verification of this assertion elsewhere.

All I can find is that aspirin inhibits platelet aggregation, modulates signaling through NF-KB, and may induce NO production. I don't see where/how it affects the clotting factors to affect PT/INR.

Any thoughts?

Thanks!

not correct, kaplan's master the board has tons of typos/misinformation: warfarin inhibits production of vitamin K-dependent clotting factors

aspirin is an irreversible COX inhibitor and interrupts platelet function/aggregation (no effect on clotting factors, at least nothing that you will have to know for USMLE).

 

[evilbooyaa]

Change Aspirin to Warfarin and that statement is right.

Otherwise that statement is 100% incorrect. Danger, Will Robinson.

 

[sprin001]

ya, not aspirin...

 

[MrBeauregard]

Damn. I was gonna buy that book, too. Now I'm not so sure with an error like that.

 

[evilbooyaa]

Damn. I was gonna buy that book, too. Now I'm not so sure with an error like that.

As odd as this sounds, I would be more ok with blatant errors that are easily catchable like that than subtle ones that I didn't already know and therefore may take on merit.

For example, if a book told me S. Aureus was a gram negative coccobacillus, I would laugh.

If a book told me that Listeria was a gram negative coccobacillus, I would realize that I don't exactly remember what Listeria was, and believe that it was a GNR.

 

[MrBeauregard]

^^ Good point.