ATP generation

[Chga]

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Through many different book different amount is listed. But what is the net ATP generation from 1 mole of glucose. Which one would be right for DAT?

 

[hawkeye712]

I would say 36 ATP for eukaryote but 38 ATP for prokaryote.

 

[aznnytezx]

IDEALLY, it is 38 ATP. The reason why prokaryote is 38 ATP, because they do not have a mitochondria (an organelle). With that being said, eukaryotes produce 36 ATP per glucose because it essentially cost 2 ATP to transfer from cytosol to mitochondria. Remember, glycolysis happens in the cytosol. Where do we get our ATP from? The Mitochondria. So we must transfer the molecule from cytosol to mitochondria. I hope that helps you understand the concept!

 

[Chga]

Here is my count

GLYCOLYSIS: glucose into pyruvate (in the cytosol)
Phosphorylation of glucose -1
Phosphorylation of fructose 6-phosphate -1
Dephosphorylation of 2 molecules of 1,3-BPG +2
Dephosphorylation of 2 molecules of phosphoenolpyruvate +2
2 NADH are formed in the oxidation of 2 molecules of glyceraldehyde 3-phosphate

Conversion of pyruvate into acetyl CoA (inside mitochondria)
2 NADH are formed

Citric acid cycle (inside mitochondria)
2 molecules of guanosine triphosphate are formed from 2 molecules of succinyl CoA +2
6 NADH are formed in the oxidation of 2 molecules each of isocitrate, alpha-ketoglutarate, and malate
2 FADH2 are formed in the oxidation of 2 molecules of succinate

Oxidative phosphorylation (inside mitochondria)
2 NADH formed in glycolysis each yields 1.5 ATP (assuming transport of NADH by the glycerol phosphate shuttle) +3
2 NADH formed in the oxidative decarboxylation of pyruvate; each yields 2.5 ATP +5
2 FADH2 formed in the citric acid cycle;each yields 1.5 ATP +3
6 NADH formed in the citric acid cycle;each yields 2.5 ATP +15

So 32 ATPs formed, with net yield at 30 ATPs