Becoming a physician scientist with only an MD

This forum made possible through the generous support of SDN members, donors, and sponsors. Thank you.

Goofy Goober

Certified Nerd
5+ Year Member
Joined
Apr 1, 2020
Messages
75
Reaction score
19
Points
511
Location
A cornfield in Illinois
  1. Pre-Medical
I've discovered that I really enjoy research and have taken an extra year in medical school to get an MS in clinical investigation while working on several clinical research projects.

I did very well on Step 2 (267) but am not sure if I can compete with MD/PhDs for spots in PSTPs. What are the other ways to becoming an RO1 funded physician scientist?

Do I apply categorical IM and then pursue research during fellowship? Do I do a postdoc? Can I stay general IM and do this?

I appreciate any insight, especially from those who might have walked this path.
 
There are several mechanisms.

You need to get on a T32 or a R38 during training. You can also consider applying for an F32 if you find the right mentor and institutional support.

Then as above, a K08 or K23 (those are junior faculty level awards). Maybe end up at an institution with a K12 program when you look for a faculty position.

And if all of the above don’t work out, find a good hypothesis and apply for R03s and R21s.

Persistence is the best pathway to an R01
 
There are several mechanisms.

You need to get on a T32 or a R38 during training. You can also consider applying for an F32 if you find the right mentor and institutional support.

Then as above, a K08 or K23 (those are junior faculty level awards). Maybe end up at an institution with a K12 program when you look for a faculty position.

And if all of the above don’t work out, find a good hypothesis and apply for R03s and R21s.

Persistence is the best pathway to an R01
Thanks for the response!

If I am applying to categorical residency programs then I should prioritize academic programs with these sorts of opportunities?

Should the research and grants come during a postdoc after residency or during fellowship? I am trying to form a timeline in my head to get a better idea of this process.
 
Thanks for the response!

If I am applying to categorical residency programs then I should prioritize academic programs with these sorts of opportunities?

Should the research and grants come during a postdoc after residency or during fellowship? I am trying to form a timeline in my head to get a better idea of this process.
If you want to do research, yes. The NIH throws a lot of dollars at training programs and having been a reviewer on a number of K study sections, you need those training programs to 1) get time to get extra research experience 2) get publications and 3) show you are willing to put in the opportunity cost regarding a career in research.

Those training programs can be in either residency or fellowship. R38 programs are only for residents if I recall. F32s (individual) and T32s (institutional) can be either residency or fellowship and carry a max 3-years on the grant.

You mentioned post-doc. I don’t think of a post-doc for MDs. While you are technically a post-doc after MD training, for MDs, that is residency, not research. A research post-doc is more oriented to PhDs who need additional oversight and skills based training. In any case, pursuing research with an MD (or an MD-PhD) requires you to complete residency (and additional subspeciality if desired). You just have to fit research into that training.

Since you are asking for examples… my path was summer research fellowship during medical school (I did not do a PhD), categorical pediatrics (there I looked for opportunities to do research on my own… there were no formal programs where I went), fellowship on a T32 with extended training time, K08 in second year of faculty, R in year 7 of faculty. There were probably also 20+ failed grant submissions in all of that.
 
Last edited:
I've discovered that I really enjoy research and have taken an extra year in medical school to get an MS in clinical investigation while working on several clinical research projects.

I did very well on Step 2 (267) but am not sure if I can compete with MD/PhDs for spots in PSTPs. What are the other ways to becoming an RO1 funded physician scientist?

Do I apply categorical IM and then pursue research during fellowship? Do I do a postdoc? Can I stay general IM and do this?

I appreciate any insight, especially from those who might have walked this path.

At this stage what you need to do is identify a residency program that will provide you significant protected time for research. This may be a PSTP, but does not have to be.

I am not familiar with current competitiveness for PSTP slots in IM. Some programs may not be able to fill all their PSTP slots with MD/PhDs, in which case you could be competitive with an MD + research year. If your home program has a PSTP, I would ask for a brief meeting with the director to try to understand more about how realistic this is for you. Otherwise talk to your dean or the PD of the regular IM residency at your program about it.

Some programs also have formalized PGY4 research 'capstone' projects that end up as QA fluff for those not interested, but can be productive research time for those with sufficient background and motivation.

I would definitely try to match at a program that has a T32. These are NIH-funded slots for research fellowships after residency, and they are usually filled by internal candidates and often are not very competitive to obtain. As long as you have the desire and financial ability to commit to 2+ years of 80-100% research after residency (which you essentially will have to do in order to become a majority-time researcher in academia), it will be a viable option in a residency that has a T32 program. Without an available T32, you will need to find your own funding to cover post-residency research time, which is a lot more work and has lower probability of success.

You then use the time in the T32 to accumulate preliminary data and apply for a career development award (K series).

Agree that categorical makes the most sense, as a separate intern year will contribute nothing to a research trajectory.

When you do your interviews, ask the program PDs about 1) availability of protected research time in residency and 2) whether there is a T32 program. Also try to gauge from the PD's level of enthusiasm in answering these questions whether they are likely to be supportive of your interest in research. Ideally, aim to match someplace where all three of these criteria are met.

After that, your research trajectory will be up to your productivity and persistence during residency and research fellowship, together with a huge serving of blind luck.
 
Last edited:
Thanks for the response!

If I am applying to categorical residency programs then I should prioritize academic programs with these sorts of opportunities?

Should the research and grants come during a postdoc after residency or during fellowship? I am trying to form a timeline in my head to get a better idea of this process.
Honestly you should apply for both categorical and PSTP. Yes 99% of the applicant pool is MD/PhD but if you have a clear vision for how to incorporate research into your career, a PSTP is a nice mechanism for those interested in academic medicine. I had some friends that were really research heavy and only MD-only that regretted only applying categorical since their profile screamed research but they didn't lean into it.

In the PSTP, the post-doc is usually integrated into the backend of your clinical fellowship. I'm still early in the PSTP journey but glad I don't have to burn the midnight oil grinding away research for fellowships. Especially since I ended up at a pretty high powered program and already working quite a lot of hours as an intern.
 
Top Bottom