Blood hemolytic reactions.

[aspiringmd1015]

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there was a uw questoin about patient with igA def, received blood and developed anaphlyaxis. easy to diagnose, but in the explanatoin it said that ABO incompatibility cannot be associated with anaphlyaxis bc theres no igE involved, as in igA def, you get igE antibodies against igA. But a/c to Goljan, goljan said that in ABO incompatibility/Acute hemolytic transfusion reaction, bc its igG and igM activating the complement, you get c3a and c5a anaphlyatoxins and that can lead to anaphlyaxis....So.....

 

[Phloston]

I'm not an allergist so I've never been overly pedantic regarding the terminology here, but anaphylaxis = immune vs non-immune; for the immune kind, it's the classic IgE-mediated response that you're already aware of; for non-immune, it's other things that trigger degranulation (e.g., drugs). Perhaps because the complement peptide anaphylatoxins (i.e., C3, 4 and 5 a) are immune-related but don't cause the IgE-based response, it's not considered a true anaphylaxis, but rather a response that resembles it. That's just my thought. But once again, this isn't UpToDate or an allergist speaking, just a forum opinion.