I'm only a lowly MS4 who is hoping to match this year, but i think i might have some decent advice.
3rd year:
-Honor as many rotations as you can, make sure to pick up some good letters along the way.
-Be open to all your rotations and show interest, not only will it help you do better during third year, but you may find a field you may enjoy as much as ophtho...you can apply to more than 1 specialty in case you're worried about going unmatched.
-Start getting to know the ophtho people at your home school, maybe do a third year elective (if offered) and try to impress the attendings
-Plan to take step 2 early in 4th year
4th year:
-Rock step 2 and make sure you do it early enough for the sfmatch
-The programs that are most likely to overlook step one are the programs that really know you, ie: your home program and programs where you did away rotations. Consider rotating at 1-2 programs where you think you have a good shot. For example, I wouldn't do both aways at wills and bascom-palmer. However, there is the argument that you may want to rotate at 1 great program in hopes of getting a great letter from someone well known...
-get your application in early, and make sure you apply to a broad range of programs
There may be more things, and I'll add them to the list as i think of them