Buspar vs. Seroquel @ D2

[firedoor]

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Apparently buspar has a stronger D2 affinity than does seroquel (buspar has a D2 Ki of 360, whereas seroquel's is 626 [489 for norquetiapine]).

Can anyone explain the clinical relevance of this?

Buspar's PI does warn of a risk of TD, but is this really of clinical concern? Similarly, how do these numbers relate to seroquel clinically?

 

[firedoor]

So I have it on rumor that Buspar may preferentially bind (inhibitory) presynaptic D2 autoreceptors, thereby enhancing dopaminergic neurotransmission.

???

 

[9point75]

It goes like this... Seroquel when you're trying to treat through personality disorder and BuSpar when you're actually trying to treat an axis I.

 

[firedoor]

Has anyone seen EPS/TD with buspar?

 

[firedoor]

Does anyone augment with Buspar?

 

[whopper]

I've given out Buspirone quite a bit for antidepressant augmentation.

I've never seen TD or EPS or any type of D2 blockage side effects from it. The fact that it binds to D2 receptors does not mean it's blocking it. It could be agonizing it. I don't have my Stahl book on me now, so that's why I'm not checking it this second.

I've seen a lot of good with Buspirone as an augmentation agent, especially if it's for an anxiety disorder or depression with comorbid anxiety I've rarely seen people have side effects to it other than sexual.