Can someone answer these 2 questions?

[superoxide]

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2) female neonate has hypotonia. complication of pregnancy was polyhydramnios. mother has no facial expression and weak muscles; she had no problems as an infant or child. what explains the difference in presentation in mother and child?
a) anticipation
b) delayed onset
c) genetic heterogeniety
d) incomplete penetrance
e) pleitropy

i think (a) is the answer (does she have myotonic dystrophy?)


3)what is the consequence of overdose of iron sulfate by 2 year old boy?
a) gastric bleeding
b) met. alkalosis
c)polycythemia
d) respiratory depression
e) urinary retention

i think (a) is the answer (???)😕

 

[path problems]

i think you're right on both of those.

 

[superoxide]

i think you're right on both of those.

Thanks

Another question: according to FA, anemia of chronic disease is normocytic, but according to goljan rapid review path (pg 123) it is classified as microcytic😕

 

[werd]

Thanks

Another question: according to FA, anemia of chronic disease is normocytic, but according to goljan rapid review path (pg 123) it is classified as microcytic😕

it can be either. you can dx it by low serum iron/high ferritin/low TIBC (i think).

 

[path problems]

according to Robbins,

In anemia of chronic disease, "the rbcs can be normocytic and normochromic or hypochromic and microcytic as in anemia of iron deficiency. The presence of increased storage iron in the marrow macrophages, a high serum ferritin level, and reduced total iron-binding capacity readily rule out iron deficiency as the cause of anemia".

I remember one NBME question where the pt. was anemic, I think his labs had increased storage iron, but the picture, or some other presentation I can't completely remember showed a microcytic anemia. The key was to realize he had a chronic disease and was storing up iron. But the answer choices had both iron deficieny and acd. Go for acd.

 

[superoxide]

Thanks. I was thinking that too. Its just that I had made up my little acronym for microcytic anemias (SATI for Sideroblastic anemia, Anemia of chronic disease, Thalassemia and Iron deficiency)...i guess that can go out the window