Can someone clarify this for me? Re: Tissue Hypoxia and MI.

[Knicks]

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Quoting from kaplan:

In a myocardial infarction (MI), myocytes swell as the membrane potential collapses and the cell gets leaky. Enzymes are released from the damaged tissue, and lactic acidosis contributes to protein precipitation and coagulation necrosis.

Requesting clarification about:

-why does the membrane potential collapse (and what does that exactly mean, that it goes to zero?)

-why does a collapsed membrane potential cause the myocytes to swell and get leaky?


Thanks in advance.


(Note: please answer if you're sure.)

 

[plainfacts]

Umm no oxygen->no ATP->no energy for ionpumps->cells cant uphold their membrane potential and the water follow the ions making the cell swell.