Cardiac contractility

[Ycut]

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What is the mechanism beyond decreasing contractility in acidosis ?

 

[baglococcus]

In acidosis, the amount of H+ in the blood is buffered to some extent by its movement into cells. As a result, K+ leaves cells. As K+ leaves the cells throughout the body, a hyperkalemic state develops. This alters the electrochemical gradients in the cardiac tissue, and consequently decreases contractility.

for more info:
http://www.uptodate.com/contents/potassium-balance-in-acid-base-disorders

 

[Ycut]

In acidosis, the amount of H+ in the blood is buffered to some extent by its movement into cells. As a result, K+ leaves cells. As K+ leaves the cells throughout the body, a hyperkalemic state develops. This alters the electrochemical gradients in the cardiac tissue, and consequently decreases contractility.

for more info:
http://www.uptodate.com/contents/potassium-balance-in-acid-base-disorders

Hyperkalemic state causes problems with excitability but how does it affect contractility ?

 

[gyrus321]

apparently increasing intracellular H causes decreased sensitivity of the contractile elements to Ca

http://onlinelibrary.wiley.com/doi/10.1111/j.0954-6820.1976.tb05871.x/abstract


i thought hyperkalemia causes depolarization but maybe thats with primary hyperkalemia. not sure if it would apply to hyperkalemia secondary to acidosis.

 

[Ycut]

Thx guys