Disclaimer: I've met Carl a few times and know several of his former trainees. I was aware of his drug use history (he has been open about that for years), but not ongoing use of anything besides cannabis. I'm mildly surprised, but far from shocked.
While the nature of the content is obviously wildly different than what we may be used to seeing, I think this is a classic case of academic overstating their case in a public messaging effort. Many of his points are backed by decades of rigorous science and have absolute merit. Many individuals can use illicit drugs without experiencing problems. Many "addicts" can make rational decisions regarding drug use. The neurobiological effects of drugs are often wildly overstated. These are all fundamentally true. The positive effects of drugs are downplayed or ignored in science and I think that is ultimately holding us back from making real progress on this issue. I could give a whole seminar on where I think NIDA and other similar entities have steered us wrong with regards to understanding and addressing problems related to drug use.
That said, I can't disagree with most of what has been posted either. Cocaine is indisputably cardiotoxic and can easily wreak havoc administered in the wrong dose to the wrong person. Carl absolutely knows this. I think he views this as politics and offering a counterpoint to mainstream. Largely a social justice issue because of the impact the broader discourse has had on already disadvantaged communities. Maybe there is something to that, but I think he (significantly) oversteps in some of these statements.