Cd45, cd45ro, uchl1, ptprc

[sleeping beauty]

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CD45RO, just like CD45RA, CD45RB... is an isoform of CD45 (LCA), which is a protein tyrosine phosphatase (remove phosphate).

another name for CD45RO is UCHL1, which is a deubiquitination enzyme (remove ubiquitin).

Does anyone know whether CD45RO is a phosphatase or a deubiqutination enzyme?

 

[deleted314957]

Tha latter. It is more formally known as ubiquitin carboxyl-terminal esterase.

 

[sleeping beauty]

Tha latter. It is more formally known as ubiquitin carboxyl-terminal esterase.

thanks. that's what I think too.

What about CD45 isoform CD45RO? any usage in diagnosis?
http://en.wikipedia.org/wiki/PTPRC

 

[pathomatic]

in ALPS, the double negative T cells are also negative for CD45R0, in tht context it helps if you get a lymph node from a patient and you are suspecting ALPS