Step II Celiac Sprue: Best Initial Test

[futuredoctor10]

MTB states that anti-tissue transglutaminase is the best first test for Celiac

I have heard endomysial antibody in the past.

Anyone know which is more accurate?

 

[evilbooyaa]

As a third one, I've learned anti-gliadin is the best initial test previous to my step 2 studying.

I don't think an exam will ask you between those 3 antibodies. In case it does, I will probably go with transglutaminase as I would rather trust Fischer than whatever I've learned previously.

 

[Rostam]

Both anti-endomyseal and anti-tissue transglutaminase have equal sensitivity. Anti-gliadin is no longer is use due to less sensitivity.

 

[futuredoctor10]

Thanks! And yes, I agree I doubt they will make us pick between all 3 antibodies.

 

[JRjcu08]

Uptodate:
"As a general rule, testing should begin with serologic evaluation. Immunoglobulin A (IgA) anti-tissue transglutaminase (TTG) antibody is the single preferred test for detection of celiac disease in individuals over the age of two years."

 

[futuredoctor10]

Uptodate:
"As a general rule, testing should begin with serologic evaluation. Immunoglobulin A (IgA) anti-tissue transglutaminase (TTG) antibody is the single preferred test for detection of celiac disease in individuals over the age of two years."

Thanks! So TTG it is then!!!