An electron weighs 1/2000 as much as a proton. So if you lost two electrons, you would change the weight 3 positions past the decimal point. You wouldn't even notice...
...or would you? Go check out a periodic table sometime. There are a few elements whose atomic mass is known to an absurd number of places past the decimal. Manganese (Mn, element 25) is usually one of them. If Mn ionizes, which it often does in many different ways, it would affect the atomic mass listed.
It wouldn't affect your calculations much, since surely some other measured value isn't known to 6 significant figures, but I have always thought this was an interesting bit of trivia!