CML karyotype

[Dr.serotonin]

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karyotype for CML shows elongation of chromosome # 9 . but we know in CML there is fusion of BCR-ABL fusion resulting in Philadelphia chromosome which is chromosome #22. I thought this 22 should elongate, No?

 

[Kazaki]

No

 

[Reperfused]

It's a swap. The portion of 22 translocating to 9 is larger than the portion of 9 translocating to 22. Hence, 9 is elongated whereas 22 is shortened.

Hope this pic clears it.

 

[Dr.serotonin]

thanks . got it