I know Goljan talks about how important this is, but I think that may be his bias as a hematopathologist. It may be important in practice, but I'd be really surprised if you ever have to do such a calculation on Step 1. There may be a rare situation where you CAN opt to do it and it could yield some potentially helpful info, but I doubt it would ever be the turning point of any question. I don't know of anyone who's even had a retic count given in a Step 1 question, but I'll ask around a bit more now as I'm getting curious.