DAT biology question of the day Golgis function

[510586]

---

Members don't see this ad.

Hi everyone. So in the DAT question of the day for April 18, it says that Golgi does glycosyllation, the adding or removing of sugar from the protein. Doesn't the rough er create glycoproteins by attaching polysaccharides to polypeptides (according to cliffs)? I thought all the Golgi does is modify and package proteins/lipids into vesicles?

 

[PocketRocket]

One of ER fxns: (as stated on Wikipedia)

• Initial glycosylation as assembly continues. This is N-linked (O-linking occurs in the Golgi).
  • N-linked glycosylation: If the protein is properly folded, Oligosaccharyltransferase recognizes the AA sequence NXS or NXT (with the S/T residue phosphorylated) and adds a 14-sugar backbone (2-N-acetylglucosamine, 9-branching mannose, and 3-glucose at the end) to the side-chain nitrogen of Asn.

In other words, the Golgi apparatus, along with the ER, contains a set of glycosyllation enzymes that attach sugar monomers to proteins as the proteins move through the apparatus. The ER is responsible for initial glycosyllation (Nitrogen-linked). Post-translational modification of proteins will happen in Golgi where the protein can undergo Oxygen-linked glycosyllation.

I didn't know about this before looking it up on wiki today so I hope this is right

 

[510586]

Thanks. Hopefully destroyer covers this because I didn't see it in Cliffs.

 

[PocketRocket]

Honestly though, I would think that knowing the fact that glycosyllation can occur both at the ER and Golgi is enough for the DAT. Breadth over depth as they say

 

[510586]

Yea and that the golgi modifies polypeptides in more ways than just glycosyllation I guess.