Deep brain stimulation for Parkinson's

[Transformers]

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Whoops meant to put this in the step 1 thread....

In Parkinson's, my understanding is that the indirect pathway (inhibitory or slow movements) is in overdrive...aka:

Stn stimulating Gpi which inhibits the thalamus

In terms of surgical options, correct me if I am wring, but it seems to make sense for you to either knock out Stn or Gpi to let the thalamus stimulate movement.

Hence, stereotactic surgery aka pallidotomy or stn-removal would work.

For DBS, when I read online, why are the targets GPi and Stn and NOT the thalamus...aka why are you further "stimulating" the inhibitory component ....or am I mistaken and instead, does DBS "inhibit" the GPi and STN
Thanks

 

[IndiaInk567]

This was confusing to me, too. High frequency DBS suppresses neural activity. That's the key. It does not stimulate which is what it seems like it would do. So it works like surgical removal.

 

[Transformers]

This was confusing to me, too. High frequency DBS suppresses neural activity. That's the key. It does not stimulate which is what it seems like it would do. So it works like surgical removal.

Ahh that makes sense