Destroyer BIO question 242

[rippinitez]

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Hi guys,

On question 242 of Destroyer bio, the answer states that the curve will shift to the right if the pH was decreased. I understand that more oxygen is unloaded as pH increases, but I don't see how this would shift the graph to the right. If anyone can clarify, it would be a great help. Thanks!

 

[hdu]

Are you talking about the influence of PH on the saturation curve of Hemoglobin?

If so, recall that high concentrations of protons (it is the same as low pH) decreases the affinity of Hemoglobin for Oxygen, so it is necessary a higher partial pressure of Oxygen to obtain the same saturation of the hemoglobin, and that is why the curve shifts to the right.

I hope it helps!

My blog www.biochemistryquestions.wordpress.com

 

[rippinitez]

Your explanation makes perfect sense. Thanks!

 

[acupofchai]

the lower pH shifts the Hb curve right because acidic conditions are indicative of actively metabolizing tissues. The shift right means lower affinity for O2 which allows O2 to be delivered at a higher rate to these oxygen-hungry tissues.

 

[yakuza]

Are you talking about the influence of PH on the saturation curve of Hemoglobin?

If so, recall that high concentrations of protons (it is the same as low pH) decreases the affinity of Hemoglobin for Oxygen, so it is necessary a higher partial pressure of Oxygen to obtain the same saturation of the hemoglobin, and that is why the curve shifts to the right.

I hope it helps!

My blog www.biochemistryquestions.wordpress.com

Can you further explain the bolded?

 

[hdu]

Can you please, write the bolded here? I have not seen the question.