Destroyer Bio Question

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Question 170
For those who don't have the book, the question this:
A particular triplet of bases in a DNA coding sequence is GGA. The anticodon on the tRNA that binds mRNA codon is:


The solution states this:
Recall DNA first makes mRNA
GGA = DNA
CCU = mRNA
thus GGA = tRNA

I don't understand the concept behind this, my genetics knowledge is a bit fuzzy, since the answer is asking for tRNA I thought the correct answer was CCU. Can anyone explain this?
 
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The mRNA codon is complemented by the tRNA anticodon, so it should mirror the DNA triplet (but with uracil). DNA/tRNA are both "connect" to the mRNA codon, so they will be the same sequence.
 
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For this question though, it states that the "DNA coding sequence" is GGA, not the "DNA noncoding / template sequence." Shouldn't the mRNA created reflect this fact (i.e., be GGA itself based on the CCT template) ? This would mean that the tRNA anticodon that binds this mRNA is CCU.

Or is this perverting the "coding sequence" interpretation too far? I was under the assumption that the coding sequence was the non-template, i.e. the mRNA formed would be the same as the non-template strand.
 
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coding sequence = GGA
template = CCT
mRNA = GGA
tRNA anti = CCU
pretty sure

otherwise "coding sequence" =/= coding strand
 
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Bumping an old thread because i suck at Genetics as well..
Does "DNA coding sequence" mean the DNA antisense strand? I'm trying to get the terminology right.
 
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Toothachee101 said:
Bumping an old thread because i suck at Genetics as well..
Does "DNA coding sequence" mean the DNA antisense strand? I'm trying to get the terminology right.
Click to expand...

The coding sequence is the "sense" strand. This is the strand that has the same coding sequence as the mRNA (only mRNA has Uracil instead of thymine). The Template strand, is the strand that RNA polymerase binds to, this is called "Antisense strand" or a Noncoding strand, since it does not have the sequence that is read by the ribosomes during protein synthesis.
Hope this helps.
 
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orgoman22 said:
The coding sequence is the "sense" strand. This is the strand that has the same coding sequence as the mRNA (only mRNA has Uracil instead of thymine). The Template strand, is the strand that RNA polymerase binds to, this is called "Antisense strand" or a Noncoding strand, since it does not have the sequence that is read by the ribosomes during protein synthesis.
Hope this helps.
Click to expand...

I'm also confused about this problem :/

Since the coding sequence is the same as the sense strand, and the problem states that the coding sequence is GGA, wouldn't that mean the mRNA should also be GGA? If that's the case, then the tRNA would be CCU?
 
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SDDDAT said:
I'm also confused about this problem :/

Since the coding sequence is the same as the sense strand, and the problem states that the coding sequence is GGA, wouldn't that mean the mRNA should also be GGA? If that's the case, then the tRNA would be CCU?
Click to expand...

Yup that's what i get. I'm confused about this as well.
@orgoman22 so if GGA is the sense strand,
5'GGA3' (coding sequence or sense strand)
3'CCT5' (non-sense strand i.e. the template used to make RNA)
5'GGA3' (mRNA)
3'CCU5' (tRNA)

This is what i get. I still don't get the right answer!
 
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Toothachee101 said:
Yup that's what i get. I'm confused about this as well.
@orgoman22 so if GGA is the sense strand,
5'GGA3' (coding sequence or sense strand)
3'CCT5' (non-sense strand i.e. the template used to make RNA)
5'GGA3' (mRNA)
3'CCU5' (tRNA)

This is what i get. I still don't get the right answer!
Click to expand...
You are correct. Template strand is not a coding strand. However, destroyer never said that it is a coding strand. By tje term "coding sequence", the question simply meant that it is the sequence that RNA polymerase binds to.
The new terminology, although correct, can make the material more complicated than it needs to be.

Hope this helps.
 
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orgoman22 said:
You are correct. Template strand is not a coding strand. However, destroyer never said that it is a coding strand. By tje term "coding sequence", the question simply meant that it is the sequence that RNA polymerase binds to.
The new terminology, although correct, can make the material more complicated than it needs to be.

Hope this helps.
Click to expand...
Thank you for clearing it up! I'm glad i got the process right.
 
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coding sequence = GGA
template = CCT
mRNA = GGA
tRNA = CCU
This is what i get. I don't understand why the answer is GGA? Isn't the question asking what is on the place of tRNA?
 
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flossit said:
coding sequence = GGA
template = CCT
mRNA = GGA
tRNA = CCU
This is what i get. I don't understand why the answer is GGA? Isn't the question asking what is on the place of tRNA?
Click to expand...

The coding sequence is not the same as the coding strand. The mRNA is made off the coding sequence - so GGA (coding sequence) would become CCU (mRNA), and the corresponding tRNA that binds it would be GGA.
 
Last edited:
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Illumident said:
The coding sequence is the DNA template that is used to make mRNA.

If you have a coding sequence of GGA, then RNA polymerase will bind to it creating:

mRNA (codon) will be CCU

tRNA (anticodon) will be GGA

You may be confusing the terminology of a coding sequence (essentially the DNA template) with coding strand (essentially mRNA).

With a coding sequence, you do not need to create the DNA template before transcribing.

With a coding strand, you would need to derive your template and your initial answer would have been correct.
Click to expand...
Omg so clear now! Thank you!
 
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