Discarded prtoeins are found in the lymph?

[inaccensa]

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I thought they get broken by lysosome or other ubiquitin pathway? One of EK's q is asking whether old blood cells or proteins discarded by tissues are found in the lymphatic system

 

[Bumbl3b33]

I thought they get broken by lysosome or other ubiquitin pathway? One of EK's q is asking whether old blood cells or proteins discarded by tissues are found in the lymphatic system

yup, proteins can leak out from the capillaries and some parts of nephron.

 

[Majik]

yup, proteins can leak out from the capillaries and some parts of nephron.

It's my understanding that proteins don't really leak out of capillaries. In fact, doing so would disrupt the required osmotic pressure required to bring water back to the capillaries that the hydrostatic pressure pushed out. Even in the nephrons, proteins are far to large to enter the nephrons. Only small molecules and ions such as glucose, sodium, potassium, and even aminoacids can enter the nephron.

However, old red blood cells are broken down by the spleen (primarily, which is part of the Lymphatic System) and a little bit by the liver (secondary). Proteins are broken down by nearly every cell in the Body to utilize amino acids. However, individual amino acids are further destroyed in the Liver where the Urea Cycle takes place. (Ammonia is toxic to the blood so it's converted to urea).

 

[inaccensa]

i understand both your explanations, but i was thrown off by the term "discarded"
i thought they meant waste