Discrepancy in Clindamycin Mechanism of Action

[wanderluste]

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Uworld says clinda acts like macrolides and prevents translocation...Uptodate and First Aid say it inhibits peptide transfer. Does anyone know for sure? i know it's s smaller point.

 

[SLC]

Goodman and Gillman and Epocrates both simply state that Clindamycin binds the 50s subunit and suppresses protein synthesis.

Goodman and Gillman also says that Clindamycin is similar to Erythromycin in it's in vitro activity; make of that what you will. It could just mean that they both act at the 50S subunit; but they did single Erythromycin out, and Erythromycin is a macrolide.

 

[coolforschool]

Uworld says clinda acts like macrolides and prevents translocation...Uptodate and First Aid say it inhibits peptide transfer. Does anyone know for sure? i know it's s smaller point.

It inhibits translocation. You might be looking at an older edition of First Aid. It's in the errata for the FA2012 edition, and FA2013 says it's translocation. It's shown up a lot, so definitely know it.

 

[SLC]

It inhibits translocation. You might be looking at an older edition of First Aid. It's in the errata for the FA2012 edition, and FA2013 says it's translocation. It's shown up a lot, so definitely know it.

FA2013 says it's peptide transfer (have it right in front of me at the moment).

But I think it's wrong, based on Goodman and Gillman's attempt to compare the MOA to erythromycin.

I'm pretty sure it's translocation, just wanted to point out that FA2013 says peptide transfer.

 

[coolforschool]

FA2013 says it's peptide transfer (have it right in front of me at the moment).

But I think it's wrong, based on Goodman and Gillman's attempt to compare the MOA to erythromycin.

I'm pretty sure it's translocation, just wanted to point out that FA2013 says peptide transfer.

Crap, you're right. It shows it correctly on the diagram though haha. I guess that should be on the next errata...

 

[wanderluste]

So go with Uworld? inhibits translocation?

 

[jozeppy26]

I'm convinced no one knows the MOA of clindamycin specifically. All that crap and like dalfopristin/quinupristin. All of it gets so overly simplified in these review books that it just ends up making things more confusing than it has to be (FA is like the sh*tiest most awesome review book all at the same time). Super annoying, haha

Anyway, this is what I went with.

 

[HoboCommander]

UWorld is usually right because they reference the latest research articles that you can look up to check.