Does the spleen make lymphocytes?

[FROGGBUSTER]

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DAT Destroyer says yes, Campbell's implies no, Yahoo answers (lol) says no.

What is the answer???

 

[UCF FINatic]

DAT Destroyer says yes, Campbell's implies no, Yahoo answers (lol) says no.

What is the answer???

Pretty sure its no. Destroyer has various mistakes in it.

 

[FROGGBUSTER]

Pretty sure its no. Destroyer has various mistakes in it.

Sigh, that's what I thought. Destroyer ****ing sucks.

 

[UCF FINatic]

Sigh, that's what I thought. Destroyer ****ing sucks.

I know. It sure is hard to study when your review material has mistakes it in. I am always second guessing everything in there now.

 

[AlbinoPolarBear]

DAT Destroyer says yes, Campbell's implies no, Yahoo answers (lol) says no.

What is the answer???

YES IT DOES.

WIKI+DESTROYER > YAHOO ANSWERS

http://en.wikipedia.org/wiki/Spleen

"As a major lymphoid organ and a central player in the reticuloendothelial system, the spleen retains the ability to produce lymphocytes and, as such, remains an hematopoietic organ."

 

[FROGGBUSTER]

YES IT DOES.

WIKI+DESTROYER > YAHOO ANSWERS

http://en.wikipedia.org/wiki/Spleen

"As a major lymphoid organ and a central player in the reticuloendothelial system, the spleen retains the ability to produce lymphocytes and, as such, remains an hematopoietic organ."

i guess i stand corrected. 😛

still don't think highly of the quality of destroyer though, we'll see.

 

[HannibalLecter]

Hannibal says no. Wikipedia can be wrong sometimes. Spleen is known as a secondary lymphoid tissue. B cells are made in the bone marrow while T cells mature in the Thymus. I know that T helper cells finish their final stage of proliferation sometimes in the spleen but this is known as secondary growth in immune system. When ever a question asks you is the spleen directly involved in making lymphocytes? That's implying does it get made there which is doesnt, it finishes proliferating. The answer is always no.

Source: Immunology for a year, god I hated that class

 

[FROGGBUSTER]

Hannibal says no. Wikipedia can be wrong sometimes. Spleen is known as a secondary lymphoid tissue. B cells are made in the bone marrow while T cells mature in the Thymus. I know that T helper cells finish their final stage of proliferation sometimes in the spleen but this is known as secondary growth in immune system. When ever a question asks you is the spleen directly involved in making lymphocytes? That's implying does it get made there which is doesnt, it finishes proliferating. The answer is always no.

Source: Immunology for a year, god I hated that class

Thanks HL. Since Campbell pretty much says this as well, I'll go with that.

 

[AlbinoPolarBear]

Thanks HL. Since Campbell pretty much says this as well, I'll go with that.

Dude, I expect nothing less than a 30 BIO from you.
You're actually reading Campbells.

You can finish off Cliffs in 2 intense days. Read Cliff's 3-4 times and it'll be good enough for a 21+ score on the biology.

 

[FROGGBUSTER]

Dude, I expect nothing less than a 30 BIO from you.
You're actually reading Campbells.

You can finish off Cliffs in 2 intense days. Read Cliff's 3-4 times and it'll be good enough for a 21+ score on the biology.

I'm actually using a mix of everything, Campbells is mostly just for clarification though. I'd definitely like a 30 though!!!

 

[AllahIsGreater]

lol the destroyer that your making fun off had 5 students from my previous dr. romano class get 25+ total science. know it inside and out, you will steam roll any kid in the nation.

 

[AlbinoPolarBear]

I'm actually using a mix of everything, Campbells is mostly just for clarification though. I'd definitely like a 30 though!!!

HAha. I'm actually excited to see your breakdown.

Don't let us down! We've had a 30 PAT, 30 QR, 30 GC, 30 OC, but highest bio was only 29 (even though he got everything right).

We're still missing those elusive 30 BIO and 30 RC.

My money for the bio is on you! GOOD LUCK!

 

[FROGGBUSTER]

lol the destroyer that your making fun off had 5 students from my previous dr. romano class get 25+ total science. know it inside and out, you will steam roll any kid in the nation.

i mean come on, you'd expect it to be error-free considering we're paying so much money for it.

 

[FROGGBUSTER]

HAha. I'm actually excited to see your breakdown.

Don't let us down! We've had a 30 PAT, 30 QR, 30 GC, 30 OC, but highest bio was only 29 (even though he got everything right).

We're still missing those elusive 30 BIO and 30 RC.

My money for the bio is on you! GOOD LUCK!

lol thanks for the encouragement.

 

[LetsGo2DSchool]

I think it does if I can remember correctly from my Microbiology textbook. I already sold the textbook so I can't look it up.

 

[indigenoustw]

Source: Immunology for a year, god I hated that class

LOL by chance you were immuno emphasis? We probably weren't in the same class. I took it last year's fall for 150/150L. I only hated my very first lecture's midterm but actually had fun throughout lol

 

[HannibalLecter]

LOL by chance you were immuno emphasis? We probably weren't in the same class. I took it last year's fall for 150/150L. I only hated my very first lecture's midterm but actually had fun throughout lol

I didn't actually hate the overall class just didn't like the in depth focus that we had. Plus our professor was not a native and so weren't our TAs. It was kind of a double whammy.

 

[UCF FINatic]

lol the destroyer that your making fun off had 5 students from my previous dr. romano class get 25+ total science. know it inside and out, you will steam roll any kid in the nation.

They probably could have had 30's if there where no errors in the Destroyer too, what a shame. 😛 I'm obviously joking, lol.

 

[NewBee12]

Yes it does. I looked up the answer on BASIC HUMAN PHYSIOLOGY by Gyton.

 

[AlbinoPolarBear]

Alright. So much hate for destroyer in these threads when Dr. Romano was actually right.

Gyton + wiki + destroyer > yahoo answers and Hannibal's gut instincts. 😛

 

[indigenoustw]

Alright. So much hate for destroyer in these threads when Dr. Romano was actually right.

Gyton + wiki + destroyer > yahoo answers and Hannibal's gut instincts. 😛

lol I wouldn't say Hannibal's wrong. Immunology is way more complicated than just saying which tissue makes "lymphocytes". There are so many kinds and so many ways these cells can arise into mature lymphocytes. Since the DAT isn't an immuno exam, I'd say spleen makes lymphocytes in response to an infection because there are T cells (in red pulp) and B cells (in white pulp) already ready to proliferate and "make" more lymphocytes (clones) to fight off infection.

Just for reference, I've attached the cell types/development of immune cells for reference from Janeway (I own the book + CD).

 

[HannibalLecter]

Alright. So much hate for destroyer in these threads when Dr. Romano was actually right.

Gyton + wiki + destroyer > yahoo answers and Hannibal's gut instincts. 😛

I am not going to try to back up what I said because recently that leads to more BS. The OP wanted to get an opinion from SDN for what the answer might be. If he wanted a real answer he would have looked at a textbook and gotten it. Since that has failed he has to rely on majority rules. I said my statement because I feel that comparing the overall knowledge known for the test 50-60% of the time when the DAT is going to ask you "Does the spleen make lymphocytes" the answer is going to be no. Because face it yes eventually later during the infection and ...

lol I wouldn't say Hannibal's wrong. Immunology is way more complicated than just saying which tissue makes "lymphocytes". There are so many kinds and so many ways these cells can arise into mature lymphocytes. Since the DAT isn't an immuno exam, I'd say spleen makes lymphocytes in response to an infection because there are T cells (in red pulp) and B cells (in white pulp) already ready to proliferate and "make" more lymphocytes (clones) to fight off infection.

Just for reference, I've attached the cell types/development of immune cells for reference from Janeway (I own the book + CD).

Just as Indigenous is saying later on during the infection it does start producing more lymphocytes because face it in critical times the body starts utilizing all of its backup stores because it needs to face an on hand infection. In the overall aspect of the DAT are they looking for that answer no. Does the DAT have immunology as a prerequisite, no. I don't know man we just need to forget about the details and start worrying about the overall concepts.

 

[Strag]

I am not going to try to back up what I said because recently that leads to more BS. The OP wanted to get an opinion from SDN for what the answer might be. If he wanted a real answer he would have looked at a textbook and gotten it. Since that has failed he has to rely on majority rules. I said my statement because I feel that comparing the overall knowledge known for the test 50-60% of the time when the DAT is going to ask you "Does the spleen make lymphocytes" the answer is going to be no. Because face it yes eventually later during the infection and ...



Just as Indigenous is saying later on during the infection it does start producing more lymphocytes because face it in critical times the body starts utilizing all of its backup stores because it needs to face an on hand infection. In the overall aspect of the DAT are they looking for that answer no. Does the DAT have immunology as a prerequisite, no. I don't know man we just need to forget about the details and start worrying about the overall concepts.

👍

 

[dentalWorks]

If I remember this crap correctly...

Spleen DOES produce antibodies and lymphocytes.

However, the spleen does NOT differentiate the lymphocytes into B or T cells (duh Bone marrow / Thymus)

 

[bharat008]

I just opened my spleen and checked it; if mine makes lymphocytes so does yours... lol

 

[FROGGBUSTER]

i dunno anymore lol.

thanks for all the replies, but i'm just going to hope this doesn't come up on the dat. lol.

 

[Vsno123]

I side with Hannibal too (I also took an entire class on immmunology). Bone marrow is the only place lymphocytes are actually MADE. Lymphocytes are in the spleen but are not made there (like he said, that's why it's a secondary lymphoid organ). I saw this error in DAT Destroyer too. Go with what you're actual textbook says.

 

[journeybegins]

I side with Hannibal too (I also took an entire class on immmunology). Bone marrow is the only place lymphocytes are actually MADE. Lymphocytes are in the spleen but are not made there (like he said, that's why it's a secondary lymphoid organ). I saw this error in DAT Destroyer too. Go with what you're actual textbook says.

I agree entirely. I just finished immunology, too.

"lymphocytes are in the spleen but are not made there." The spleen is where the mature lymphocytes go to after B/T cell development.

 

[K Niner]

I side with Hannibal too (I also took an entire class on immmunology). Bone marrow is the only place lymphocytes are actually MADE. Lymphocytes are in the spleen but are not made there (like he said, that's why it's a secondary lymphoid organ). I saw this error in DAT Destroyer too. Go with what you're actual textbook says.

I took immunology and also agree. I haven't looked up any ridiculously detailed info on the spleen, but I don't need to because this is a question for the DAT, not for your PhD in immunology. So as far as the test is concerned they may ask you something like where are b-cells made, the answer will be the bone marrow. If it ask where are t-cells made, the answer is also the bone marrow, they MATURE in the thymus.

Wikipedia states the following: "After reaching the IgM+ immature stage in the bone marrow, these immature B cells migrate to the spleen, where they are called transitional B cells, and some of these cells differentiate into mature B lymphocytes.[2]"
However, if you look at the link where the info was obtained, it states if was from the following article: "+Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells"
Obviously, this is a special scenario since this is entitled "alternative routes." Also, marginal zones are a particular histology found in the spleen, & MALT tissues, maybe others too, but that area doesn't exist in regular lymph nodes as far as I know. And this statement is about where the b-cells mature, not where they are produced. I didn't see any other info about b-cells being produced in the spleen. All lymphocytes (b & t cells are made by hematopoeitic stem cells in the bone marrow). All this to say the info stated on wikipedia is of a probably of a special situation, not that of the basic, typical physiology of the immune system. And the DAT wants to know things like B-cells make plasma cells, are produced in the bone marrow, helper t-cells stuff, bla bla, MHC stuff, CD8/4/etc., the basic stuff, not bizarre scenarios that immunologists might disagree over. So don't worry about that question, and focus on the important stuff.

 

[Bereno]

If I remember correctly I think of the spleen as a back-up manufacturing plant. It CAN produce lymphocytes, but is mostly lets the other parts of the body do the work. When those become overloaded, the spleen can then be used to supplement demand. Once again, this was my memory of it, and that could be wrong. 👍