doubt gluconeogenesis

[docasrpa]

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is glucose 6 phosphatase the rate limiting enzyme in gluconeogenesis?

 

[Sinatra Frank]

is glucose 6 phosphatase the rate limiting enzyme in gluconeogenesis?

fructose 1,6-bisphosphatase (FBP-1)

 

[docasrpa]

are u sure about this?

 

[njsmahal]

are u sure about this?

yupp thats right.
glucose 6 phosphate is limited to liver thats why in muscles glycogen cannot be converted into glucose

 

[docasrpa]

ur reply is bit doubtful
if g 6 phosphatase is limited to liver that means it becomes rate limiting.and not fruc 1 6 biphosphatase/

 

[njsmahal]

ur reply is bit doubtful
if g 6 phosphatase is limited to liver that means it becomes rate limiting.and not fruc 1 6 biphosphatase/

being rate limited is not solely dependent on being present or not.more importantly rate limiting steps are generally irreversible steps and also controlled enzymes.
so you mean to say if some individual has an enzyme deficiency then taht enzyme becomes rate limiting for some cycle for that particular individual?

just to back it up... krebs cycle doesnt occur in RBCs so are all teh enzymes of krebs cycle rate limiting??? or brain doesnt use any other fuel but glucose so are all the other enzymes in glycogenolysis, beta oxidation and protein breakdown rate limiting???

 

[Sinatra Frank]

being rate limited is not solely dependent on being present or not.more importantly rate limiting steps are generally irreversible steps and also controlled enzymes.
so you mean to say if some individual has an enzyme deficiency then taht enzyme becomes rate limiting for some cycle for that particular individual?

just to back it up... krebs cycle doesnt occur in RBCs so are all teh enzymes of krebs cycle rate limiting??? or brain doesnt use any other fuel but glucose so are all the other enzymes in glycogenolysis, beta oxidation and protein breakdown rate limiting???

that is true..(once again)
i think in biochem u need to memorize the rate limiting step for each pathway,, u cant make a general rule that will fit to all pathway.. general statment which clames that all irrversible steps are rate limiting is wrong..