EPS pathophysiology?

[Solideliquid]

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Does anyone know what is the pathophys of the involuntary movement disorders caused by neuroleptic drugs?


Thanks!

 

[Nerdoscience]

They are dopamine antagonists. Not fully understood, but part of the movement disorders is Parkinsonism, which makes sense. Conversely, overdosing on some Parkinson's meds (notably Sinemet, which includes levodopa) can lead to psychosis.