- Joined
- Apr 11, 2012
- Messages
- 194
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- 5
Extravascular hemolysis -> increase UCB -> increase CB -> darkening of stool and urine as a result. No problem here.
Now concerning lab tests: RR says that there is an increase in AST from destroyed Er. But AST is mitochondrial enzyme and Er don't have mitochondria. What's the trick then?
Thanks!
Edit:
Sorry.....just found the answer:
"Two isoenzymes are present in a wide variety of eukaryotes. In humans:
GOT1/cAST, the cytosolic isoenzyme derives mainly from red blood cells and heart.
GOT2/mAST, the mitochondrial isoenzyme is present predominantly in liver."
Now concerning lab tests: RR says that there is an increase in AST from destroyed Er. But AST is mitochondrial enzyme and Er don't have mitochondria. What's the trick then?
Thanks!
Edit:
Sorry.....just found the answer:
"Two isoenzymes are present in a wide variety of eukaryotes. In humans:
GOT1/cAST, the cytosolic isoenzyme derives mainly from red blood cells and heart.
GOT2/mAST, the mitochondrial isoenzyme is present predominantly in liver."