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- May 2, 2016
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Hi guys,
I'll preface this post with a potential apology if this question is completely ridiculous, but heme is not really my thing (i.e. everything about blood confuses me). So here goes...
Pathoma states that plasmin is responsible for cleaving fibrin and fibrinogen, which in turn has an anti-thrombotic effect. I get why cleaving fibrin would help with clot breakdown and inhibition, but why fibrinogen?
I thought the whole point of the coagulation cascade was to cleave fibrinogen to fibrin, thereby allowing formation of a stable clot. So why does cleavage of fibrinogen by plasmin cause the opposite by actually helping with degradation and prevention of a clot?
I would appreciate any clarification! For whatever reason, my IQ score temporarily drops by 30 points the moment I try learning anything about blood, so feel free to explain like I'm five - it'll probably be for the best, anyways 🙄
I'll preface this post with a potential apology if this question is completely ridiculous, but heme is not really my thing (i.e. everything about blood confuses me). So here goes...
Pathoma states that plasmin is responsible for cleaving fibrin and fibrinogen, which in turn has an anti-thrombotic effect. I get why cleaving fibrin would help with clot breakdown and inhibition, but why fibrinogen?
I thought the whole point of the coagulation cascade was to cleave fibrinogen to fibrin, thereby allowing formation of a stable clot. So why does cleavage of fibrinogen by plasmin cause the opposite by actually helping with degradation and prevention of a clot?
I would appreciate any clarification! For whatever reason, my IQ score temporarily drops by 30 points the moment I try learning anything about blood, so feel free to explain like I'm five - it'll probably be for the best, anyways 🙄