Step I Focal segmental glomerulosclerosis?

[LuckiestOne]

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In pathoma, it says that it dose not have any immune deposition and will not be identifiable by immunoflourescence.

But in one of the UWorld question (Q. ID: 9 [433705]), it says that Focal segmental glomerulosclerosis has IgM and C3 deposits...

can anyone please explain what's going on here?

 

[Phloston]

I have annotated into my FA for FSGS (from different practice questions I've done):

"segmental capillary collapse"

SS disease, heroin abuse, pamidronic acid-use

"parts of glomerular capillary tufts show obliterated capillaries, with less than 50% of the glomeruli affected"

C1 + C3 deposition (C1 is afferent arterioles; C3 in epithelium); IgM, IgG, C1, C3 all found; hyaline deposits

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So yeah, all of that info is from different practice questions, even one that asked about the approximate percentage of glomeruli affected; it's less than, not greater than, 50%.

 

[Myxedema]

Robbins Basic Pathology, 9E, p. 526:

In affected glomeruli, immunofluorescence microscopy often reveals nonspecific trapping of immunoglobulins, usually IgM, and complement in the areas of hyalinosis