Folate not needed for cytosine synthesis

[Phloston]

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I just encountered a practice question that asked about which nucleotide is not dependent on folate for synthesis.

Cytosine is the one (i.e. thymidine and the purines, A and G, are dependent on folate).

I just thought that was a good question because the bottom of p.68 of FA2012 shows that the purine structure at positions 2+8 is dependent on the N10-formyl-THF, whereas p.69 shows that thymidylate synthase requires N5N10-methylene-THF.

No, I'm not asking a question here, but I thought I'd just share that with people for the sake of reinforcement.

 

[GTP]

I learned this on gt 🙂. Gotta love that program

 

[dragon529]

I so remember that card!

 

[Phloston]

I'm actually not even doing the cards at the moment. That's just from the question bank.

 

[phoenix89]

Thanks, I didnt know that. Cheers 🙂