Gabapentin and COPD exacerbation

[soxman]

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Saw a few articles on this. I haven't really noticed any of my patients with COPD go into an exacerbation. Has anyone experienced this ?

https://www.jwatch.org/na57032/2024/01/25/gabapentin-and-pregabalin-are-associated-with-severe-copd

 

[joshmir]

Unable to view at that link

Can you post please?

 

[soxman]

Unable to view at that link

Can you post please?

Oops sorry this one may work

https://www.acpjournals.org/doi/10.7326/M23-0849

 

[Ducttape]

population based cohort study, so cant "prove" cause effect.

gabapentin group was sicker to start.

there were multiple potential limitations - a question arose as to whether the gabapentin group was more likely to be on opioids and whether they were smokers, for example.

but the trend does need to be considered - ie does gabapentin increase risk for respiratory distress.