Glaucoma predetermination

[ituryu]

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Can anyone pls give a resource website were I can really look-up the B/P IOP ratio for the early detection or predetermination of pxs who wld likely become glaucoma patients in future

 

[cpw]

I've been told blood pressure and IOP are not directly correlated.

 

[ituryu]

Well we are trying to look at values for this ratio to be able to predetermine the possibility of an individual who is likely to develop glaucoma and I was hoping to find out more about this. You Nigeria is a black society and using race criterion, glaucoma shld be a major problem right here.

 

[mdkurt]

Well we are trying to look at values for this ratio to be able to predetermine the possibility of an individual who is likely to develop glaucoma and I was hoping to find out more about this. You Nigeria is a black society and using race criterion, glaucoma shld be a major problem right here.

Check out this article. A couple population studies have correlated high systolic BP with high IOP--Barbados Eye Study (all black participants) and, I believe, the Beaver Dam Eye Study (all white).

Arch Ophthalmol. 2003 Jun;121(6):856-62. Related Articles, Links


Factors related to the 4-year risk of high intraocular pressure: the Barbados Eye Studies.

Nemesure B, Wu SY, Hennis A, Leske MC; Barbados Eye Studies Group.

School of Medicine, Stony Brook University, NY 11794, USA.

OBJECTIVE: To evaluate the 4-year risk of high intraocular pressure (IOP) and associated factors in a black population without glaucoma at baseline. DESIGN: Population-based incidence study. PARTICIPANTS: Random sample of Barbados residents aged 40 to 84 years. After 4 years, 3427 (85%) were reexamined. MAIN OUTCOME MEASURES: Development of elevated IOP (using percentile-based definitions) among individuals with an IOP of 21 mm Hg or lower and no glaucoma at baseline. Associations were evaluated using polychotomous logistic regression. RESULTS: At baseline, 2856 participants did not have glaucoma or suspected glaucoma: 361 had an IOP higher than 21 mm Hg or received treatment, and 2495 had an IOP of 21 mm Hg or lower and no treatment. At follow-up, only 58% of the 361 participants remained free of glaucoma and had an IOP higher than 21 mm Hg, whereas 30% had an IOP of 21 mm Hg or lower. Among the remaining 2495 participants, the incidence of IOP higher than 21 mm Hg or treatment (80th percentile) was 12.9% (95% confidence interval, 11.7%-14.3%). Using other definitions of elevated IOP, estimates ranged from 1.5% to 11%. Incidence increased with age, with rates 2.5 times higher at 70 years or older than at ages 40 to 49 years. Factors associated with high IOP included age, baseline IOP, hypertension, and blood pressure. Whereas participants with an IOP between 21 mm Hg and 28 mm Hg had higher blood pressure readings, those with an IOP of 21 mm Hg or lower or an IOP higher than 28 mm Hg had similar values. CONCLUSIONS: Definitions of high IOP based on percentiles may be more applicable than those based on arbitrary values. Older individuals with a higher baseline IOP were more likely to develop elevated IOP after 4 years. Although blood pressure was also associated with high IOP, the relationship may be nonlinear.

 

[Richard_Hom]

Check out this article. A couple population studies have correlated high systolic BP with high IOP--Barbados Eye Study (all black participants) and, I believe, the Beaver Dam Eye Study (all white).

Dear mdkurt,

I'm wondering if these studies can show "association" only. I would think it would be difficult to create a "nomogram" of some or other clinical tool from this unless there was more direct linkage between.

What are your thoughts between pulsatile ocular blood flow and systolic and distolic pressures?

Regards,
Richard_Hom

 

[mdkurt]

Dear mdkurt,

I'm wondering if these studies can show "association" only. I would think it would be difficult to create a "nomogram" of some or other clinical tool from this unless there was more direct linkage between.

What are your thoughts between pulsatile ocular blood flow and systolic and distolic pressures?

Regards,
Richard_Hom

Your point is well taken--these are enormous population studies. Breaking it down to individual patients is not a good idea. It sounds like ITURYU is looking to identify a risk stratification scheme for glaucoma (a daunting undertaking), so the study I referred him to seemed right up his alley. The only thing I think about re: blood flow is nocturnal hypotension + glaucoma = bad.