Glioblastoma Multiforme?

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I hear this is what Ted Kennedy got, and if you get it you're basically ****ed....

Is that true? My father said the cancer grows "fingers" into the brain and is very aggressive.
 
I hear this is what Ted Kennedy got, and if you get it you're basically ****ed....

Is that true? My father said the cancer grows "fingers" into the brain and is very aggressive.

Essentially yes. You seem like you're pre-med or in high school based on your question (I apologize if I'm wrong) so I'll keep it simple. Glioblastoma multiforme is basically the worst form of glioma. Gliomas a tumors of glial cell origin and are graded by the degree of cell differentiation. GBM is the most undifferentiated form. You should google pictures of normal astrocytes (most common cells affected by glioma) and compare them to GBM cells to really see what I mean.

Brain tumor operations for glioma/GBM are usually the first treatment, but are often just "debulking" of the main tumor mass. Those "fingers" you mentioned are pretty much untouchable without damage to the brain, and thus can't be resected completely with traditional surgery. Chemo, radiation, and surgery options are improving...but you still only have about a 5% chance of surviving more than 3 years past diagnosis.

Hope that answers your question. As I said before, I don't know your level of medical knowledge but PM me if interested and I'll try to provide literature on the subject of GBM.
 
Essentially yes. You seem like you're pre-med or in high school based on your question (I apologize if I'm wrong) so I'll keep it simple. Glioblastoma multiforme is basically the worst form of glioma. Gliomas a tumors of glial cell origin and are graded by the degree of cell differentiation. GBM is the most undifferentiated form. You should google pictures of normal astrocytes (most common cells affected by glioma) and compare them to GBM cells to really see what I mean.

Brain tumor operations for glioma/GBM are usually the first treatment, but are often just "debulking" of the main tumor mass. Those "fingers" you mentioned are pretty much untouchable without damage to the brain, and thus can't be resected completely with traditional surgery. Chemo, radiation, and surgery options are improving...but you still only have about a 5% chance of surviving more than 3 years past diagnosis.

Hope that answers your question. As I said before, I don't know your level of medical knowledge but PM me if interested and I'll try to provide literature on the subject of GBM.

Is GBM research mainly in medonc, radonc, neurology or neurosurgery?
 
Is GBM research mainly in medonc, radonc, neurology or neurosurgery?

Hard to give a good answer, besides all of the above. In terms of the type of research, I would say you could clump it mostly into medonc and rad onc (a very rough clumping). However, the people doing this research come from all of the specialties you've mentioned. From a neurosurgery point of view, there is often a focus on drug delivery, given that whole blood brain barrier problem, and the infiltrative nature of GBM: a hard problem for physicians that can't cut thru the meninges. Neurosurgeons in general are less involved with true basic research given their time constraints in the clinic and OR. However, their are many exceptions to this ie. Keith Black, Mitch Berger etc. etc.

I'll make the assumption that you are interested in glioma research and want to decide what specialty is most appropriate. If this is the case, then it depends on what kind of research you want to do. If basic science is your thing, then I'd suggest rad onc or med onc/neurology. These will give you more free time, something needed to run a successful lab. It's important to note that you can become a "neuro-oncologist" through an internal medicine or neurology route. However, overall, rad onc will probably give you the most free time outside of clinic to pursue basic research

With regards to neurosurgery, most attendings focus on clinical research ie. clinical trials, surgical approaches/techniques, collaboration with rad onc on bracytherapy and other rad delivery systems. As stated above, you can do basic research, but it's much harder. Most neurosurgeons that do basic research generally have more of a consulting role, or run a lab with the help of PhD's that have the time to be hands on and involved in the lab's daily activities.

Sorry for the long winded answer. Hope it helps.
 
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