Glue sniffing

[Pathinterpreter]

Advertisement - Members don't see this ad

What's the mechanism of glue sniffing causing normal gap metabolic acidosis?
(I want to understand)

Thank you in advance.

 

[PeepshowJohnny]

Apparently, toluene and it's metabolite hippurate (found in inhalants) induces an RTA by inhibiting the secretion of hydrogen ions/ammonium.

 

[Pathinterpreter]

Thank you very much!